Genesis 15:18
On that day the LORD made a covenant with Abram, saying, "To your descendants I have given this land--from the river of Egypt to the great River Euphrates--

Deuteronomy 1:7
Resume your journey and go to the hill country of the Amorites; go to all the neighboring peoples in the Arabah, in the hill country, in the foothills, in the Negev, and along the seacoast to the land of the Canaanites and to Lebanon, as far as the great River Euphrates.

Joshua 1:4
Your territory shall extend from the wilderness and Lebanon to the great River Euphrates--all the land of the Hittites--and west as far as the Great Sea.

Revelation 7:1
After this I saw four angels standing at the four corners of the earth, holding back its four winds so that no wind would blow on land or sea or on any tree.

Revelation 7:2
And I saw another angel ascending from the east, with the seal of the living God. And he called out in a loud voice to the four angels who had been given power to harm the land and the sea:

Revelation 16:12
Then the sixth angel poured out his bowl on the great river Euphrates, and its water was dried up to prepare the way for the kings of the East.