The title "Holy One of God" is a significant designation found in the New Testament, primarily used in reference to Jesus Christ. This title underscores the divine nature and the sanctity of Jesus, affirming His unique relationship with God the Father and His role in the divine plan of salvation.

Biblical References:

1. Mark 1:24 : The first instance of this title is found in the Gospel of Mark, where a man possessed by an unclean spirit recognizes Jesus and cries out, "What do You want with us, Jesus of Nazareth? Have You come to destroy us? I know who You are—the Holy One of God!" This acknowledgment by a demonic spirit highlights the spiritual authority and purity of Jesus, even recognized by the forces of darkness.

2. Luke 4:34 : Similarly, in the Gospel of Luke, a demon-possessed man in the synagogue at Capernaum exclaims, "Ha! What do You want with us, Jesus of Nazareth? Have You come to destroy us? I know who You are—the Holy One of God!" This parallel account reinforces the recognition of Jesus' divine holiness by spiritual entities.

3. John 6:69 : The Apostle Peter also uses this title in his confession of faith. After many disciples turn away from Jesus, Peter declares, "We believe and know that You are the Holy One of God." This statement by Peter is a profound acknowledgment of Jesus' divine identity and mission, reflecting the faith and understanding of the early disciples.

Theological Significance:

The title "Holy One of God" emphasizes the sinlessness and divine nature of Jesus Christ. In the Old Testament, holiness is a key attribute of God, often associated with His separateness from sin and His absolute moral purity. By calling Jesus the "Holy One of God," the New Testament affirms that Jesus shares in this divine holiness, setting Him apart from all other human beings.

This title also points to Jesus' role as the Messiah, the Anointed One sent by God to fulfill the promises of salvation. In the Old Testament, the term "holy one" is sometimes used to describe God's chosen servants, such as the prophets or the nation of Israel. However, in the New Testament, Jesus is uniquely identified as the Holy One, indicating His preeminence and the fulfillment of God's redemptive plan through Him.

Christological Implications:

The recognition of Jesus as the "Holy One of God" has profound implications for Christology, the study of the nature and work of Christ. It affirms the belief in Jesus' divinity, His sinless life, and His authority over spiritual realms. This title also underscores the belief in the incarnation, where the divine and holy nature of God is fully present in the person of Jesus Christ.

In summary, the title "Holy One of God" is a powerful testament to the identity and mission of Jesus Christ as the divine Savior, set apart for the purpose of redeeming humanity and establishing God's kingdom on earth.