In the biblical narrative, the concept of immunity from plagues and destruction is often associated with divine protection and covenantal promises. Throughout Scripture, God demonstrates His ability to shield His people from calamities, emphasizing His sovereignty and faithfulness.

Old Testament Instances

1. The Passover (Exodus 12): One of the most prominent examples of divine immunity is the Passover event. God instructed the Israelites to mark their doorposts with the blood of a lamb, saying, "The blood on the houses where you are staying will distinguish them; when I see the blood, I will pass over you. No plague will fall on you to destroy you when I strike the land of Egypt" (Exodus 12:13). This act of obedience provided protection from the final plague that struck Egypt, demonstrating God's power to preserve His people amidst widespread destruction.

2. The Plagues of Egypt (Exodus 7-11): During the series of plagues that afflicted Egypt, God made a distinction between the Egyptians and the Israelites. For instance, in the plague of flies, God declared, "But on that day I will set apart the land of Goshen, where My people live, so that no swarms of flies will be there, so that you will know that I, the LORD, am in this land" (Exodus 8:22). This separation underscored God's protective hand over His covenant people.

3. The Wilderness Journey (Numbers 21): When fiery serpents plagued the Israelites due to their rebellion, God provided a means of healing and protection through the bronze serpent. "Then the LORD said to Moses, 'Make a fiery serpent and mount it on a pole. When anyone who is bitten looks at it, he will live'" (Numbers 21:8). This incident highlights God's provision of a remedy and His mercy in the face of judgment.

Psalms and Wisdom Literature

1. Psalm 91: This psalm is a profound declaration of God's protection. It promises deliverance from "the deadly plague" and assures that "a thousand may fall at your side, and ten thousand at your right hand, but it will not come near you" (Psalm 91:3, 7). The psalmist emphasizes trust in God as a refuge and fortress, underscoring the security found in His presence.

2. Proverbs 3:25-26: The wisdom literature also speaks to divine protection, stating, "Do not fear sudden danger or the ruin that overtakes the wicked, for the LORD will be your confidence and will keep your foot from the snare" . This passage encourages reliance on God's safeguarding power.

New Testament Assurance

1. Jesus' Ministry: In the New Testament, Jesus' healing ministry often involved deliverance from physical ailments and demonic oppression, symbolizing spiritual and physical restoration. His authority over sickness and death is a testament to His divine power to protect and heal.

2. Revelation 7:3: In the apocalyptic vision of Revelation, God's servants are sealed for protection. "Do not harm the land or sea or trees until we have sealed the foreheads of the servants of our God" . This sealing signifies divine preservation amidst impending judgment.

Theological Implications

The theme of immunity from plagues and destruction in the Bible underscores God's covenantal faithfulness and His role as protector. It calls believers to trust in His promises and to seek refuge in His presence. While physical immunity is not always guaranteed, the spiritual assurance of God's protection remains steadfast for those who abide in Him.