GOD'S WORD® Translation
"How horrible it will be for a nation that sins. [Its] people are loaded down with guilt. They are descendants of evildoers and destructive children. They have abandoned the LORD. They have despised the Holy One of Israel. They have turned their backs on him.

American Standard Version
Ah sinful nation, a people laden with iniquity, a seed of evil-doers, children that deal corruptly! they have forsaken Jehovah, they have despised the Holy One of Israel, they are estranged and gone backward.

Berean Study Bible
Alas, O sinful nation, a people laden with iniquity, a brood of evildoers, children of depravity! They have forsaken the LORD; they have despised the Holy One of Israel and turned their backs on Him.

Douay-Rheims Bible
Woe to the sinful nation, a people laden with iniquity, a wicked seed, ungracious children: they have forsaken the Lord, they have blasphemed the Holy One of Israel, they are gone away backwards.

English Revised Version
Ah sinful nation, a people laden with iniquity, a seed of evil-doers, children that deal corruptly: they have forsaken the LORD, they have despised the Holy One of Israel, they are estranged and gone backward.

King James Bible
Ah sinful nation, a people laden with iniquity, a seed of evildoers, children that are corrupters: they have forsaken the LORD, they have provoked the Holy One of Israel unto anger, they are gone away backward.

World English Bible
Ah sinful nation, a people loaded with iniquity, a seed of evildoers, children who deal corruptly! They have forsaken Yahweh. They have despised the Holy One of Israel. They are estranged and backward.

Young's Literal Translation
Ah, sinning nation, a people heavy with iniquity, A seed of evil doers, sons -- corrupters! They have forsaken Jehovah, They have despised the Holy One of Israel, They have gone away backward.

Isaiah 1:4 Additional Translations ...