Word Origin
from dia and poneomai (to work hard)
Definition
to toil through, to be worn out or annoyed
NASB Translation
greatly annoyed (1), greatly disturbed (1).

STRONGS NT 1278: διαπονέω

διαπονέω: to work out laboriously, make complete by labor. Middle (present διαπονοῦμαι); with 1 aorist passive διεπονήθην (for which Attic writings διεπονησαμην);

a. to exert oneself, strive;

b. to manage with pains, accomplish with great labor; in secular authors in both senses (from Aeschylus down).

c. to be troubled, displeased, offended, pained, (cf. colloquial English to be worked up; Winer's Grammar, 23 (22)): Acts 4:2; Acts 16:18. (Aq. in Genesis 6:6; 1 Samuel 20:30; the Sept. in Ecclesiastes 10:9 for נֶעֱצַב; Hesychius διαπονηθείς; λυπηθείς.)

διαπονηθεις διαπονηθείς διαπονηθεὶς διαπονηθήσεται διαπονουμενοι διαπονούμενοι diaponetheis diaponetheìs diaponētheis diaponētheìs diaponoumenoi diaponoúmenoiInterlinear Greek • Interlinear Hebrew • Strong's Numbers • Englishman's Greek Concordance • Englishman's Hebrew Concordance • Parallel Texts