2:5-12 Something hindered or withheld the man of sin. It is supposed to be the power of the Roman empire, which the apostle did not mention more plainly at that time. Corruption of doctrine and worship came in by degrees, and the usurping of power was gradual; thus the mystery of iniquity prevailed. Superstition and idolatry were advanced by pretended devotion, and bigotry and persecution were promoted by pretended zeal for God and his glory. This mystery of iniquity was even then begun; while the apostles were yet living, persons pretended zeal for Christ, but really opposed him. The fall or ruin of the antichristian state is declared. The pure word of God, with the Spirit of God, will discover this mystery of iniquity, and in due time it shall be destroyed by the brightness of Christ's coming. Signs and wonders, visions and miracles, are pretended; but they are false signs to support false doctrines; and lying wonders, or only pretended miracles, to cheat the people; and the diabolical deceits with which the antichristian state has been supported, are notorious. The persons are described, who are his willing subjects. Their sin is this; They did not love the truth, and therefore did not believe it; and they were pleased with false notions. God leaves them to themselves, then sin will follow of course, and spiritual judgments here, and eternal punishments hereafter. These prophecies have, in a great measure, come to pass, and confirm the truth of the Scriptures. This passage exactly agrees with the system of popery, as it prevails in the Romish church, and under the Romish popes. But though the son of perdition has been revealed, though he has opposed and exalted himself above all that is called God, or that is worshipped; and has spoken and acted as if he were a god upon earth, and has proclaimed his insolent pride, and supported his delusions, by lying miracles and all kinds of frauds; still the Lord has not yet fully destroyed him with the brightness of his coming; that and other prophecies remain to be fulfilled before the end shall come.

12. they all … damned—rather as Greek, "that all," &c. He here states the general proposition which applies specially to Antichrist's adherents. Not all in the Church of Rome, or other anti-Christian systems, shall be damned, but only "all who believed not the truth," when offered to them, "but had pleasure in unrighteousness" (Ro 1:32; 2:8). Love of unrighteousness being the great obstacle to believing the truth.