Damasus addresses five questions to Jerome with a request for information concerning them. They are:

1. What is the meaning of the words "Whosoever slayeth Cain vengeance shall be taken on him sevenfold"? (Gen. iv.5.)

2. If God has made all things good, how comes it that He gives charge to Noah concerning unclean animals, and says to Peter, "What God hath cleansed that call not thou common"? (Acts x.15.)

3. How is Gen. xv.16, "in the fourth generation they shall come hither again," to be reconciled with Ex. xiii.18, LXX, "in the fifth generation the children of Israel went up out of the land of Egypt"?

4. Why did Abraham receive circumcision as a seal of his faith? (Rom. iv.11.)

5. Why was Isaac, a righteous man and dear to God, allowed by God to become the dupe of Jacob? (Gen. xxvii.) Written at Rome 384 a.d.