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That is, either by His own knowledge, or by their knowledge of Him. And, as Dean Plumptre puts it, the prophet may have been directed to an expression which included both. For both are true of Christ. Men are saved by knowing Him; and, on the other hand, it is His knowledge of the Father that enables Him to lead men to the Father.

(Expository Times.)

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KJV: He shall see of the travail of his soul, and shall be satisfied: by his knowledge shall my righteous servant justify many; for he shall bear their iniquities.

WEB: After the suffering of his soul, he will see the light and be satisfied. My righteous servant will justify many by the knowledge of himself; and he will bear their iniquities.