16:10-12 Timothy came to do the work of the Lord. Therefore to vex his spirit, would be to grieve the Holy Spirit; to despise him, would be to despise Him that sent him. Those who work the work of the Lord, should be treated with tenderness and respect. Faithful ministers will not be jealous of each other. It becomes the ministers of the gospel to show concern for each other's reputation and usefulness.

11. despise—This charge is not given concerning any other of the many messengers whom Paul sent. 1Ti 4:12 accounts for it (compare Ps 119:141). He was a young man, younger probably than those usually employed in the Christian missions; whence Paul apprehending lest he should, on that account, be exposed to contempt, cautions him, "Let no man despise thy youth" [Paley, Horæ Paulinæ].

conduct—set him on his way with every mark of respect, and with whatever he needs (Tit 3:13).

in peace—(Ac 15:33; Heb 11:31). "Peace" is the salutation of kindness and respect in the East; and so it stands for every blessing. Perhaps here there is too a contrast between "peace" and the "contentions" prevalent at Corinth (1Co 1:11).

I look for him—He and Titus were appointed to meet Paul in Troas, whither the apostle purposed proceeding from Ephesus (2Co 2:12, 13). Paul thus claims their respect for Timothy as one whom he felt so necessary to himself as "look for" to him [Theophylact].

with the brethren—Others besides Erastus accompanied Timothy to Macedonia (compare 1Co 16:12; Ac 19:22).